7.20pm to 8.45pm, Friday 31 January
This event has already taken place
Sir Gregory Winter was awarded the 2018 Nobel Prize in Chemistry for making monoclonal antibodies using a technique called phage display.
This talk will explore how he did this and how his earlier work led to the development of drugs such as trastuzumab (Herceptin) used to treat breast cancer, and adalimumab (Humira) used to treat rheumatoid arthritis.
Join Sir Gregory as he explores what his work means, why it was such a breakthrough and what new medicines could be created in the future.
Sir Gregory Winter studied Natural Sciences at the University of Cambridge. He then completed his PhD at the LMB, working on the amino acid sequence of tryptophanyl tRNA synthetase from the bacterium Bacillus stearothermophilus. His research career has been based almost entirely at the LMB and the MRC Centre for Protein Engineering (CPE). He became a Programme Leader in 1981, was Joint Head of the PNAC Division from 1994-2006, Deputy Director of the LMB from 2006-2011 and acting Director 2007-2008. He was also Deputy Director of CPE from 1990 until its closure in 2010.
His main research focus is genetic and protein engineering. In his early research Gregory was interested in the idea that all antibodies have the same basic structure, with only small changes making them specific for one target. He pioneered techniques in humanised and human therapeutic antibodies, which led to antibody therapies for cancer and diseases such as rheumatoid arthritis and multiple sclerosis. He has established hugely successful spin out companies including: Cambridge Antibody Technology (acquired by AstraZeneca), Domantis (acquired by GlaxoSmithKline) and Bicycle Therapeutics.
He is a Fellow of Trinity College, Cambridge and has been Master of Trinity since 2012. He was elected a member of the European Molecular Biology Organisation in 1987, a Fellow of the Royal Society in 1990 and Fellow of the Academy of Medical Sciences in 2006, as well as being a Fellow or Honorary Fellow of many other professional organisations. He has been awarded numerous prizes and medals, including the 2018 Nobel Prize for Chemistry. He received a Knighthood for services to Molecular Biology in 2004.
Discourses are one of the Ri’s oldest and most prestigious series of talks. Since 1825, audiences in the theatre have witnessed countless mind-expanding moments, including the first public liquefaction of air by James Dewar, the announcement of the electron by JJ Thomson and over 100 lectures by Michael Faraday. In more recent times, we have had Nobel laureates, Fields medal winners, scientists, authors and artists – all from the cutting-edge of their field. Discourses are an opportunity for the best and brightest to share their work with the world.
Steeped in nearly two centuries of tradition, a Discourse is more than just a lecture. To keep the focus on the topic, presenters begin sharply at 7:30pm without introduction and we lock the speaker into a room ten minutes ahead of the start (legend has it that a speaker once tried to escape!). Some of our guests dress smartly for our Discourse events to add to this sense of occasion.
Find out more about the history of the Friday Evening Discourses on our blog.
Please be aware that this Discourse starts at 7.30pm, but all attendees must be seated in the theatre by 7.20pm.
The doors will open at approximately 6.45pm.
Latecomers will be admitted to the gallery.
The theatre is on the first floor. We have step-free access from street to theatre.
The closest underground station is Green Park, which is step-free.
There is space at floor level in the theatre for wheelchair users.
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Our theatre is equipped with an Audio Induction Loop.
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