The first model which demonstrates the structure of an enzyme, providing an explanation for how enzymes speed up a chemical reaction in terms of its physical structures. First mapped by David Chilton Phillips & Louise Johnson’s research team in 1965 by x-ray diffraction methods.
This is a model of lysozyme, the second protein but first enzyme structure to be solved by x-ray diffraction.
Lysozyme is an enzyme found in the tears and nasal mucus of humans and animals, and it can also be found in the whites of eggs. Discovered in 1921 by Sir Alexander Fleming, one of lysozyme’s functions is to protect the cornea of the eye from infection.
While holding the position of Director of the Davy Faraday Research Laboratory at the Royal Institution, William Lawrence Bragg continued to build up and supervise research teams of young scientists. It was his third team of research students, led by David Phillips and Louise Johnson, who successfully tackled the structures of complex organic crystals, finally mapping the structure of Lysozyme in the early 1960s.